Contact
Email: gwenaelle.andre@inrae.fr
INRAE |
Research interest
I work as a structural computational biologist at Inrae, on the Campus of Jouy-en-Josas, in MaIAGE: Applied Mathematics and Computer Science, from Genome to Environment. This lab is headed by Dr. B. Laroche, and has a co-sharing divisions of MIA (Applied Mathematics and Informatics) and MICA (Microbiology and Food Chain). I belong to the StatInfoMics team headed by Dr. M. Mariadassou. My principal interest deals with structural and computational bioinformatics, to infer sequence/structure/function/dynamics of proteins, mainly those of the ESKAPE group, deeply involved in Antibio-Microbial Resistance (AMR). AMR is a major threat worldwide and the major cause of mortality by 2050. In line with that, and in collaboration with N. Rama Rao from Micalis, and J-C Cintrat form CEA, we have a current focus in potentiating selected hits into leads to optimise the inhibition of Mfd -Mutation frequency decline- an innovative target involved in DNA repair and mutational evolutions in bacteria.
My second interest deals with prokaryotic signaling through phosphorylation/ dephosphorylation events, mediated by protein Ser/Tyr/Thr kinases/phosphatases, respectively. In line with that my (small ) team has fruitful collaboration with virologists, structuralists and biochemists from Argentina and Uruguay.
I am also deeply involved in collaborative projects. For all my projects, i combine structural and computational bioinformatics, molecular modeling expertise, X-ray crystallography skills, with in vitro/in vivo data from my collaborators, whose methods span biophysics, biochemistry, microbiology.document it .
Skills and Expertise
PDB - DNA - Proteins - Modelling and Docking - Molecular Dynamics Simulation - Structural Bioinformatics - Structure Prediction - Protein Structure - Computational Structural Biology - Molecular Visualization
Publications
All my publications and communications are available on HAL INRAE and ResearchGate
Keywords
- Bioinformatique structurale
- Modélisation moléculaire
- Analyse séquence/structure/fonction
- Criblage des MetaOmics
- Bioinformatique
- Microbiote instestinal
Educations
- Cornell University
- Visiting Assistant Professor, modelisation moléculaire
- 1999 - 2000
- Activités et associations : Structural bioinformatics; Food Science
- Université des Sciences et Techniques de Nantes - France
- Doctorat de Sciences, Modélisation moléculaire
- 1994 - 1998
- Niveau : Caractérisation structurale et fonctionnelle de l'amylase d'orge AMY2
- Université des Sciences et Techniques de Nantes
- DEA , Physico-chimie des BioproduitsDEA
- 1993 - 1994
- Niveau : DEA
- Université des Sciences et Techniques de Bretagne Occidentale
- Maîtrise, Chimie organique
- 1992 - 1993
- Université de Bretagne Occidentale
- Licence de Chimie, Chimie organique
- 1991 - 1992
- Université de Bretagne Occidentale
- DEUG-A, Physique, Chimie, Mathématique, Informatique
- 1989 - 1991