Mathématiques et Informatique Appliquées
du Génome à l'Environnement

 

 

 

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André Gwenaëlle

 

 

Contact

Email: gwenaelle.andre@inrae.fr


Adress: 

INRAE
MaIAGE Unit
Domaine de Vilvert - Bat 233
78352 JOUY-EN-JOSAS CEDEX

 Gwenaelle André

Research interest

I work as a structural computational biologist at Inrae, on the Campus of Jouy-en-Josas, in MaIAGE: Applied Mathematics and Computer Science, from Genome to Environment. This lab is headed by Dr. B. Laroche, and has a co-sharing divisions of MIA (Applied Mathematics and Informatics) and MICA (Microbiology and Food Chain). I belong to the StatInfoMics team headed by Dr. M. Mariadassou. My principal interest deals with structural and computational bioinformatics, to infer sequence/structure/function/dynamics of proteins, mainly those of the ESKAPE group, deeply involved in Antibio-Microbial Resistance (AMR). AMR is a major threat worldwide and the major cause of mortality by 2050. In line with that, and in collaboration with N. Rama Rao from Micalis, and J-C Cintrat form CEA, we have a current focus in potentiating selected hits into leads to optimise the inhibition of Mfd -Mutation frequency decline- an innovative target involved in DNA repair and mutational evolutions in bacteria.

My second interest deals with prokaryotic signaling through phosphorylation/ dephosphorylation events, mediated by protein Ser/Tyr/Thr kinases/phosphatases, respectively. In line with that my (small ) team has fruitful collaboration with virologists, structuralists and biochemists from Argentina and Uruguay.

I am also deeply involved in collaborative projects. For all my projects, i combine structural and computational bioinformatics, molecular modeling expertise, X-ray crystallography skills, with in vitro/in vivo data from my collaborators, whose methods span biophysics, biochemistry, microbiology.document it .

Skills and Expertise

PDB - DNA - Proteins - Modelling and Docking - Molecular Dynamics Simulation - Structural Bioinformatics - Structure Prediction - Protein Structure - Computational Structural Biology - Molecular Visualization

Publications

All my publications and communications are available on HAL INRAE and ResearchGate

 

Keywords

  • Bioinformatique structurale
  • Modélisation moléculaire
  • Analyse séquence/structure/fonction
  • Criblage des MetaOmics
    • Bioinformatique
    • Microbiote instestinal

Educations

  • Cornell University 
    • Visiting Assistant Professor, modelisation moléculaire
    • 1999 - 2000 
    • Activités et associations : Structural bioinformatics; Food Science
  • Université des Sciences et Techniques de Nantes - France 
    • Doctorat de Sciences, Modélisation moléculaire
    • 1994 - 1998
    • Niveau : Caractérisation structurale et fonctionnelle de l'amylase d'orge AMY2
  • Université des Sciences et Techniques de Nantes 
    • DEA , Physico-chimie des BioproduitsDEA
    • 1993 - 1994 
    • Niveau : DEA
  • Université des Sciences et Techniques de Bretagne Occidentale 
    • Maîtrise, Chimie organique
    • 1992 - 1993
  • Université de Bretagne Occidentale 
    • Licence de Chimie, Chimie organique
    • 1991 - 1992 
  • Université de Bretagne Occidentale 
    • DEUG-A, Physique, Chimie, Mathématique, Informatique
    • 1989 - 1991

 

Publications