Age-related diseases are a major healthcare issue for older populations, burdening personal relationships, healthcare systems, and economies. Incidence of cancer, cardiovascular, pulmonary, kidney, neurodegenerative, metabolic, mobility, and immune disorders rises with longer life spans. Because every tissue undergoes damage and functional decline during ageing, healthcare faces the challenge of which diseases to treat and with what strategies. A key research focus is slowing cellular damage to delay the “ageing clock.” Understanding and targeting this clock presents major AGE-LIFT opportunities for prevention and treatment of age-related diseases.