PHHASt

By pinicolas, 7 décembre, 2021
Equipe(s)
Agence de moyen
Etat
Titre du projet
Phenotypic heterogeneity and host adaptation during late infection in sporulating Firmicutes
Nom de l'appel d'offre
AAPG2022
DĂ©fi/axe ANR
CE20 Biologie des animaux, des organismes photosynthétiques et des micro-organismes
Coordinateur.trice
L. Slamti
Participants de MaIAGE
S. Dérozier, C. Guérin, P. Nicolas
Partenaires (hors MaIAGE)
L. Slamti (MICALIS), F. Neulat-Ripoll (IRBA)
Année de démarrage - Année de fin de projet
2022-2026
Date de fin du projet
Résumé
Pathogenic bacteria must constantly adapt to environmental changes during infection. Our results show that the entomopathogenic bacterium Bacillus thuringiensis has developed an alternative to sporulation to survive in the host cadaver. This study, focused on bacteria of the Bacillus cereus group, pathogenic to humans and animals, aims to characterize this state, which has been obscured by sporulation, considered for a long time as the only survival strategy in spore-forming firmicutes. Our objective is to characterize the regulatory networks underlying this physiological state by implementing complementary global and targeted methods at the population and cellular level, using molecular biology, flow cytometry, an animal model and bioinformatics analyses. This project will allow the understanding of a new mechanism leading to phenotypic heterogeneity allowing bacteria to persist in their niche and potentially adapt more rapidly to environmental changes. This research could open new perspectives for the control of spore-forming pathogenic bacteria.
Année de soumission
2021