Safety pharmacology is an essential process to study new molecules.
It tooks part in the early phases (in vitro) of the cycle life of a possible futur drug.
Currently, patch clamp is the reference technique to study the impact of a molecule on the electrical activity of cardiac cells. It is however slow and expensive. A recent device (MEA) allows a fast screening of molecules on cardiac tissues. These new electrical signals are nevertheless poorly understood. Our studies focus on three main points:
- The simulation of the MEA signals to enrich an experimental database.
- The development of a goal oriented dimension reduction method based on a classification score.
- The construction of a training set based on a classification score.
We will particularly focus on these first two points and some classification applications.