Systems Biologists combine data and models from various sources. Data often come in the form of spreadsheet or table files. SBtab is a set of syntax rules and conventions that simplify data processing and thereby facilitate data exchange. The conventions include, for example, defined column names and a syntax for semantic annotations. Models can be automatically interconverted between SBtab and SBML. SBtab is supported by software code for Python, Matlab, and R. A validation tool and a conversion to the SBML model format are available online.