Séminaire

Organisme intervenant (ou équipe pour les séminaires internes)
Warwick Medical School, University of Warwick
Nom intervenant
Christopher Quince
Titre
Probabilistic Modelling of Microbial Community Structure
Résumé

I will give an overview of methods that use generative probabilistic models to describe microbial community structure as determined through next generation sequencing. I will discuss the concept that the human gut microbiota is derived from a finite number of discrete types or enterotypes. I will show that Dirichlet-multinomial mixtures allow a more nuanced description of enterotypes as diffuse peaks in community configurations. I will then extend the idea of Dirichlet priors for community configurations to hierarchical Dirichlet processes which allow ‘unseen’ species to be modelled. I will use these both as a means for fitting the ecological model, Hubbell’s Unified Neutral Theory of Biodiversity, and for avoiding rarefaction in microbial community diversity estimation.

Lieu
Salle de réunion 142, bâtiment 210
Date du jour