Lundi 4 mars 2019


Intervening organization
Humboldt, Universität zu Berlin, Institut of Theoretical Biology
Name of intervener
Ralf Steuer
Cellular resource allocation and the architecture of phototrophic growth

The potential offered by cyanobacteria will undoubtedly play a major role in mastering the challenges of the 21st century – from securing global food supply to the synthesis of renewable raw materials. As yet, however, fundamental questions regarding the metabolic principles of cyanobacterial phototrophic growth are not resolved: How are metabolic, photosynthetic, and ribosomal proteins optimally partitioned during phototrophic growth? What is the highest growth rate a cyanobacterium can attain?
The presentation will describe our recent efforts to answer these questions using experimental and constraint-based computational models: we describe phototrophic growth as a cellular resource allocation problem and estimate the costs and benefits of all metabolic constituents of a cyanobacterial cell. Of particular interest are the cellular organization that enables fast phototrophic growth and the corresponding intracellular limits on growth rates. The model-derived resource allocation is in good agreement with experimental findings. I will provide an outlook how such analyses has implications for ecology and models of global biogeochemical cycles.

[1] Zavřel T(*), Faizi M, Loureiro C, Poschmann G, Stühler K, Sinetova M, Zorina A, Steuer R(*), Červený J (2019) Quantitative insights into the cyanobacterial cell economy. eLife  [* corresponding authors]
[2] Faizi M, Zavrel T, Loureiro C, Cerveny J, Steuer R (2018) A model of optimal protein allocation during phototrophic growth. Biosystems 166, 26-36.
[3] Reimers AM, Knoop H, Bockmayr A, Steuer R (2017) Cellular trade-offs and optimal resource allocation during cyanobacterial diurnal growth. Proc Natl Acad Sci U S A. Pii: 201617508.
[4] Westermark S and Steuer R (2016) Toward multiscale models of cyanobacterial growth: a modular approach. Front. Bioeng. Biotechnol. 4:95.
[5] Knoop H, Gruendel M, Zilliges Y, Lehmann R, Hoffmann S, Lockau W, Steuer R (2013) Flux balance analysis of cyanobacterial metabolism: The metabolic network of Synechocystis sp. PCC 6803. PLoS Comput Biol 9(6): e1003081.

Salle de réunion 142, bâtiment 210
Date of the day